Peptides & Peptide Conjugates

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 TirzPharm offers a complete range of peptide synthesis and manufacturing services, catering to both clinical and commercial-scale production. With extensive knowledge in solid-phase (SPPS), liquid-phase (LPPS), and hybrid-phase synthesis methods, we provide high-quality peptides that include linear sequences (up to 40 amino acids) as well as intricate branched peptides and conjugates with lipids, PEGs, carbohydrates, and small molecules.

 Our specialized peptide R&D laboratories located in Hyderabad, along with our commercial GMP manufacturing facility, which is audited by international regulatory authorities such as the US FDA, MHRA, and PMDA, facilitate smooth technology transfer, scaling up, and production of peptide APIs in quantities of up to 10–12 kg per batch. 

• SPPS, LPPS, and hybrid peptide synthesis
• Peptidomimetics, cyclic peptides, cysteine-rich peptides, lactam-bridged peptides
• Peptides with multiple disulfide bridges, stapled peptides, and fluorescent/dye-labeled peptides
• Custom peptide-linker synthesis for drug conjugation applications

• Current SPPS Scale-up: 10 kg input & 30–35 kg RBP (resin-bound peptide) output
• Global deprotection: 20 kg input → 10 kg output
• API Batch Sizes: 20–39 amino acids → 1.2 kg per batch
• Facility supports ~10 kg peptide API per batch
• Planned scale-up to 25 kg input → 70–75 kg RBP output

• Liberty Pro Peptide Synthesizer (25 L)
• Automated microwave peptide synthesizers (lab & commercial scale)
• Manual SPPS reactors (100 mL to 10 L)
• Automated synthesizers (80–160 L) for large-scale peptide production

• Preparative RP-HPLC (150–600 mm columns, 3.3–20 LPH) with PAT blending
• Automated ion-exchange resin systems (Akta Explorer, Akta Prime Plus)
• MPLC system (250 mL/min), gel permeation chromatography
• Crystallization, precipitation, and membrane-based TFF (1 kDa–10 kDa)
• Freeze dryers: 3 L, 1.5 L, and 100 L programmable capacity
• Closed-loop filtration via Hastealloy ANFDs (1 m²)

• LCMS, GC-MS, LC-ToF, LC Orbitrap, MALDI-ToF
• 600 MHz NMR, Circular Dichroism (CD) for secondary structure analysis
• Multi-angle Light Scattering (MALS)
• Charged Aerosol Detector (CAD) for HPLC
• Amino acid analyzer with post-column derivatization

• cGMP manufacturing blocks dedicated to peptides and polymers
• Class 100K cleanroom facilities with lyophilization capabilities
• Fully qualified systems for impurity profiling and regulatory submissions
• Manufacturing facilities inspected by US FDA, MHRA, PMDA, ensuring global regulatory compliance

• Broad technical capability—from feasibility and route scouting to commercial manufacturing
• Ability to handle standard, complex, and customized peptide formats
• Seamless integration of synthesis, purification, and analytics
• Proven expertise, infrastructure, and scalability for global clinical supply