Oligonucleotide

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 We are your reliable provider of oligonucleotide synthesis services, delivering dependable support for custom oligonucleotide synthesis and advanced characterization tailored to the requirements of research and clinical applications. Our cutting-edge laboratory facility, backed by proficient scientists, enables us to provide custom phosphoramidite synthesis and execute intricate conjugations utilizing click chemistry, amide coupling, and thiol-mediated C-S & S-S bond formation. 

We are capable of synthesizing 10-40 mer oligonucleotides at scales of up to 10 grams and can accommodate all modifications. Our dedicated 25,000 sq. ft. laboratory space is outfitted with humidity control and storage capacity, ensuring optimal conditions for producing high-quality results. 

• ÄKTA oligosynt oligonucleotide synthesizer (10 µmol to 12 mmol ) for DNA/RNA synthesizer
• AKTA pure150 purification system
• ÄKTA flux 6 TFF System for concentration, desalting
• benchtop tray lyophilizer
• Agilent LC-MS for oligonucleotide analysis
• Nano spectrophotometer

• Scale: 10 µmol to 12 mmol
• Size: 10 to 40-mer
• All standard modifications
• Anion/ Cation exchange purification
• Reverse phase HPLC
• Size exclusion
• Desalting

• UV quantification
• Purity and identity analysis using LC-MS (TOF) and mass deconvolution
• HPLC with different mobile and stationary phase for purity assessment

• Acid-amine coupling
• Alkyne-azide coupling
• Thiol-maleimide coupling
• S-S and C-S bond formation