Heterocyclic Compounds

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At Bachem Pharm, we bring comprehensive capabilities in the field of heterocyclic chemistry, supporting the needs of pharmaceutical, agrochemical, and advanced material industries. Our integrated approach combines synthetic innovation, process efficiency, analytical precision, and regulatory excellence.

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• Proficient in the synthesis of a wide range of heterocycles, including both aromatic (pyridines, pyrimidines, quinolines) and non-aromatic/fused systems (imidazoles, oxazoles, thiazoles, triazoles).
• Skilled in assembling simple and complex ring systems, multi-functionalized heterocycles, and highly substituted frameworks.

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• Expertise in catalytic methodologies such as palladium-catalyzed cross-coupling and transition metal-mediated functionalizations.
• Ability to handle high-temperature, high-pressure, cryogenic, and moisture-sensitive reactions required for challenging heterocyclic constructs.

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• Route scouting, optimization, and scale-up from milligram to multi-kilogram quantities.
• Emphasis on cost-effective, sustainable, and scalable manufacturing processes.
• Risk assessment and process safety evaluations integrated into development cycles.

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• Advanced purification techniques including flash chromatography, preparative HPLC, and crystallization methods tailored to heterocycles.
• Comprehensive analytical support with NMR (1D and 2D), LC-MS, HRMS, FTIR, and elemental analysis ensuring structural confirmation and purity profiling.

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• Processes aligned with global regulatory requirements (ICH, cGMP for applicable stages).
• Full traceability and documentation to support IND, NDA, or other regulatory filings.
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• Capable of supporting projects from early research and preclinical stages through to clinical and commercial production.
• Flexible manufacturing approaches including batch and continuous flow processes for efficient scale-up of heterocyclic compounds.

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• Dedicated team of experienced synthetic chemists, process scientists, and analytical experts.
• Constant focus on adopting new technologies and synthetic strategies to tackle increasingly complex heterocyclic challenges.

Our deep-rooted expertise in heterocyclic chemistry ensures the successful delivery of high-quality, innovative solutions, driving progress across discovery and development pipelines.

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